Potential of damage associated molecular patterns in synergising radiation and the immune response in oesophageal cancer.

Noel E Donlon,Maria Davern,Andrew Sheppard,Fiona O'Connell,Brendan Moran,Timothy S Nugent,Aisling Heeran,James J Phelan,Anshul Bhardwaj,Christine Butler,Narayanasamy Ravi,Claire L Donohoe,Niamh Lynam-Lennon,Stephen Maher,John V Reynolds,Joanne Lysaght

World journal of gastrointestinal oncology（2023）

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摘要

In conclusion, OAC expresses an immunogenic phenotype with two distinct subgroups of high and low DAMP expressors, which correlated with tumour regression grade and lymphatic invasion. It also identifies DAMPs namely CRT and HMGB1 as potential promising biomarkers in predicting good pathological responses to conventional chemo(radio)therapies currently used in the multimodal management of locally advanced disease.

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cancer,radiation,immune response

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