Levels of Synaptic Proteins in Brain and Neurofilament Light Chain in Cerebrospinal Fluid and Plasma of OVT73 Huntington's Disease Sheep Support a Prodromal Disease State.

Ellen Sapp,Adel Boudi,Suzanne J Reid,Bianca A Trombetta,Pia Kivisäkk,Toloo Taghian,Steven E Arnold,David Howland,Heather Gray-Edwards,Kimberly B Kegel-Gleason,Marian DiFiglia

Journal of Huntington's disease（2023）

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摘要

These results show that synaptic changes occur in brain of 5- and 10-year-old OVT73 sheep, but levels of NfL in biofluids are unaffected. Altogether, the data support a prodromal disease state in OVT73 sheep that involves the caudate, putamen and cortex.

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