Krüppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice

Kemmei Ikuta,Shinya Hayashi,Kenichi Kikuchi,Masahiro Fujita,Kensuke Anjiki,Yuma Onoi,Shotaro Tachibana,Yoshihito Suda,Kensuke Wada,Yuichi Kuroda,Naoki Nakano,Toshihisa Maeda,Tomoyuki Matsumoto,Tetsuya Hosooka,Wataru Ogawa,Ryosuke Kuroda

Osteoarthritis and cartilage（2024）

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摘要

Our results indicated that the OA phenotype of KLF15 KO DMM mice was influenced by reduced PPARγ expression, including enhanced pIKKα/β, ADAMTS5, and MMP13 expression, reduced autophagy, and increased apoptosis. KLF15 regulation may constitute a possible therapeutic strategy for the treating OA.

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关键词

osteoarthritis,receptor gamma,ppel-like,proliferator-activated

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