Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells.

Paul V Dellorusso, Melissa A Proven,Fernando J Calero-Nieto,Xiaonan Wang,Carl A Mitchell,Felix Hartmann,Meelad Amouzgar,Patricia Favaro,Andrew DeVilbiss,James W Swann,Theodore T Ho,Zhiyu Zhao,Sean C Bendall,Sean Morrison,Berthold Göttgens,Emmanuelle Passegué

bioRxiv : the preprint server for biology（2023）

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摘要

Autophagy compensates for chronic inflammation-induced metabolic deregulation in old HSCs, and its transient modulation can reset old HSC glycolytic and regenerative capacity.

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关键词

autophagy,glycolytic impairment,hematopoietic stem cells,aging,inflammation-driven

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