Multiple psychiatric polygenic risk scores predict associations between childhood adversity and bipolar disorder

Kai Yao,Tracey van der Veen,Johan Thygesen,Nick Bass,Andrew McQuillin

Journal of affective disorders（2023）

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摘要

•Increased polygenic risk for ADHD was associated with increased ACE reporting•Higher BD PRS was associated with increased odds of developing psychotic symptoms•Increased ADHD PRS was associated increased odds of developing rapid cycling•No significant interaction effect between ACE and any PRSs (BD/ADHD/MDD/SCZ) could be found

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关键词

Polygenic risk score,Bipolar disorder,Attention-deficit/hyperactivity disorder,Major depressive disorder,Schizophrenia,Adverse childhood experiences

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