Effect of GRK4 on renal gastrin receptor regulation in hypertension.

Xuewei Xia, Yongchun Zeng,Zhuxin Li,Hao Luo,Wei Wang,Yanji He,Bingjun Lu,Jingwen Guo,Ken Chen,Xiang Xu

Clinical and experimental hypertension (New York, N.Y. : 1993)（2023）

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摘要

GRK4 participates in the development of hypertension by regulating the phosphorylation of renal CCKBR leading to impaired CCKBR function and water and sodium retention. Knockdown of GRK4 restored the function of CCKBR. The enhanced co-connection between GRK4 and CCKBR may be an important reason for the hyperphosphorylation of GRK4 and CCKBR involved in the pathogenesis of hypertension.

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关键词

Essential hypertension, GRK4, gastrin, CCKBR, Na+-K+-ATPase

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