Prevotella copri alleviates sarcopenia via attenuating muscle mass loss and function decline.

Xiaolei Liu,Jiqiu Wu,Jingyi Tang,Zhigang Xu,Bailing Zhou,Yang Liu,Fengjuan Hu,Gongchang Zhang,Rui Cheng,Xin Xia,Yilong Chen, Hongyu Wu,Daoming Wang,Jirong Yue,Biao Dong,Jingyuan Fu,Haopeng Yu,Birong Dong

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

The results indicated that there were lower levels of both P. copri and BCAA in sarcopenia individuals. In vivo experiments, gavage with LPC could attenuate muscle mass and function decline, indicating alleviating sarcopenia. This suggested that P. copri may play a therapeutic potential role in the management of sarcopenia.

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关键词

Brand chain amino acid, Gut microbiome, Prevotella copri, Sarcopenia, Serum metabolome

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