Durable Anti-Vi IgG and IgA Antibody Responses in 15-Month-Old Children Vaccinated With Typhoid Conjugate Vaccine in Burkina Faso

Alphonse Ouedraogo,Amidou Diarra,Issa Nebie,Nouhoun Barry,Jean Moise Kabore,Alfred B. Tiono,Shrimati Datta,Yuanyuan Liang, Ifayet Mayo, Jennifer J. Oshinsky,J. Kathleen Tracy,Tsion Girmay,Marcela F. Pasetti,Leslie P. Jamka,Kathleen M. Neuzil,Sodiomon B. Sirima,Matthew B. Laurens

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY（2023）

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摘要

We assessed anti-Vi IgG/IgA responses to typhoid conjugate vaccine (TCV) in children enrolled in a double-blind randomized controlled, phase 2 trial in Burkina Faso. Anti-Vi IgG seroconversion and anti-Vi IgA titers were higher in TCV than control recipients at 30-35 months post-vaccination. TCV induces durable immunity in Burkinabe children vaccinated at 15 months.

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Africa,Burkina Faso,IgA and IgG,immunogenicity,typhoid conjugate vaccine

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