Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension.

Circulation research（2023）

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摘要

By maintaining endothelial mitochondrial homeostasis, deSUMOylation of FIS1 adaptively preserves pulmonary endothelial function against hypoxic stress and consequently protects against PH. The FIS1 deSUMOylation-SUMOylation transition in pulmonary endothelium is an intrinsic pathogenesis of hypoxic PH.

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关键词

endothelial cells, hypertension, pulmonary, hypoxia, mitochondria, sumoylation

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