Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord.

Qingying Liu,Zhongyuan Lu,Huan Ren,Lijun Fu, Yueliang Wang,Huilian Bu,Minyu Ma,Letian Ma, Chen Huang,Jian Wang,Weidong Zang,Jing Cao,Xiaochong Fan

Journal of bone oncology（2023）

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摘要

These findings suggest that spinal Cav3.2 T-type calcium channels play a central role during the development of bone cancer pain in rats via regulation of the IGF-1/IGF-1R/HIF-1α pathway.

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关键词

bone cancer pain,calcium,rat spinal cord,cav32,t-type

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