Association of Physical Inactivity with MRI Markers of Brain Aging: Assessing Mediation by Cardiometabolic and Epigenetic Factors.

Nicole L Spartano,Ruiqi Wang,Qiong Yang,Ariel Chernofsky,Joanne M Murabito,Daniel Levy,Ramachandran S Vasan,Charles DeCarli,Pauline Maillard,Sudha Seshadri,Alexa S Beiser

Journal of Alzheimer's disease : JAD（2023）

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摘要

Our results suggest that cardiometabolic risk factors and epigenetic patterns partially mediate the associations of physical inactivity with lower brain volume, higher white matter diffusivity, and aggregation of free water in the extracellular compartments of the brain.

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关键词

brain aging,physical inactivity,cardiometabolic,mri markers

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