EBNA1 Inhibitors Block Proliferation of Spontaneous Lymphoblastoid Cell Lines From Patients With Multiple Sclerosis and Healthy Controls.

Maria Chiara G Monaco,Samantha S Soldan,Chenhe Su, Annaliese Clauze, John F Cooper, Rishi J Patel,Fang Lu, Randall J Hughes,Troy E Messick,Frances C Andrada,Joan Ohayon,Paul M Lieberman,Steven Jacobson

Neurology(R) neuroimmunology & neuroinflammation（2023）

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摘要

This study shows that patient-derived SLCLs provide a useful tool for interrogating the role of EBV B cells in MS and suggests that a clinical trial testing the effect of EBNA1 inhibitors in MS may be warranted.

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关键词

multiple sclerosis,spontaneous lymphoblastoid cell lines,inhibitors

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