Harmonin inhibits presynaptic Ca v 1.3 Ca 2+ channels in mouse inner hair cells

Harmonin was previously identified as a scaffolding protein that is important for the localization of cadherin in the upper tip-link density of the stereociliary membrane and for the initial mechanotransduction event in inner hair cells. Here the authors find that harmonin is involved in regulating the voltage-gated calcium channel for synaptic transmission in inner hair cell ribbon synapses.