57. Depression as a Disease of White Matter Network Disruption: Characterizing the Relationship Between White Matter Lesions and Depression in Patients With Multiple Sclerosis

Erica B. Baller, Elizabeth Sweeney,Amit Bar‐Or,Matthew Cieslak,Sydney Covitz, John A. Detre,Ameena Elahi, Abigail Manning,Clyde Markowitz, Melissa Martin,Christopher Perrone, Victoria Rautman, Timothy Robert-Fitzgerald,Matthew K. Schindler,Shan Siddiqi, Sunil Thomas,Michael Fox,Russell T. Shinohara,Theodore Satterthwaite

NEUROPSYCHOPHARMACOLOGY（2023）

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摘要

Multiple sclerosis(MS) is an immune-mediated neurological disorder, with up to 50% of patients experiencing a lifetime depression. This study aims to define how depression in adults with MS is associated with white matter lesion(WML) location and burden.

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关键词

multiple sclerosis,white matter lesions,white matter network disruption,depression,disease

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