Di(2-ethylhexyl) phthalate mediates IL-33 production via aryl hydrocarbon receptor and is associated with childhood allergy development.

Mei-Lan Tsai,Shih-Hsien Hsu,Li-Ting Wang,Wei-Ting Liao,Yi-Ching Lin,Chang-Hung Kuo,Ya-Ling Hsu,Ming-Chu Feng,Fu-Chen Kuo,Chih-Hsing Hung

Frontiers in immunology（2023）

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摘要

Cord blood IL-33 level was correlated to childhood allergy and associated with maternal DEHP exposure. IL-33 might be a potential target to assess the development of DEHP-related childhood allergic disease. Flavonoids might be the natural antidotes for DEHP.

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关键词

childhood allergy development,phthalate mediates,aryl hydrocarbon receptor

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