Mapping high-grade glioma immune infiltration to 5-ALA fluorescence levels: TCGA data computation, classical histology, and digital image analysis.

Alexandra Lang,Raphael L Jeron,Bastian Lontzek,Barbara Kiesel,Mario Mischkulnig,Anna S Berghoff,Gerda Ricken,Adelheid Wöhrer,Karl Rössler,Daniela Lötsch-Gojo,Thomas Roetzer-Pejrimovsky,Walter Berger,Johannes A Hainfellner,Romana Höftberger,Georg Widhalm,Friedrich Erhart

Journal of neuro-oncology（2023）

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摘要

With mapping the immune infiltration pattern of different 5-ALA categories, we are adding fundamental basic insights to the field of 5-ALA and glioma biology. The observation that a significant correlation in TCGA data did not fully translate to detectable differences in immune infiltration in first histology data warrants further investigation in larger cohorts.

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关键词

5-ALA, High-grade glioma, Glioblastoma, Histology, Immune cells, CD8, CD168, CD63, FoxP3, Automated imaging processing

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