NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation

Elliott M. Bernard,Petr Broz

Molecular cell（2023）

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摘要

Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al. implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules.

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关键词

necrotic cell death,cell death,inflammation

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