Timing matters: A protective role of astrocyte reactivity in neurodegeneration
Neuron(2023)
摘要
Sheehan and Nadarajah et al. identified that Bmal1 loss from astrocytes induces the expression of BAG3, a macroautophagy chaperone enriched in Alzheimer's disease patients and in disease-associated astrocytes, enhancing the phagocytosis of misfolded proteins and preventing tau and alpha-synuclein pathologies.
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关键词
astrocyte reactivity
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