Treatment Response in First-Line Metastatic Pancreatic Ductal Adenocarcinoma Is Stratified By a Composite Index of Tumor Proliferation and CD8 T-Cell Infiltration.

Gregory L Beatty,Devora Delman,Jiayi Yu,Mingen Liu,Joey H Li,Liti Zhang,Jae W Lee,Renee B Chang,Nathan Bahary,Eugene P Kennedy,Andrea Wang-Gillam,Gabriela R Rossi,Ignacio Garrido-Laguna

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Our findings suggest that inhibiting cancer cell proliferation alone in PDA is insufficient to produce tumor responses and support a role for tumor-extrinsic mechanisms, such as CD8+ T cells, which combine with the cancer cell proliferation index to define treatment outcomes.

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