Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals.

It is still unclear how much plasma biomarkers contribute to identification of AD pathology across the AD spectrum beyond the information already provided by demographics (age + sex). Plasma p-tau231 and p-tau217 contribute to demographic information to identify brain Aβ pathology in preclinical AD. In CI individuals, plasma p-tau231 contributes to age and sex to inform on the accumulation of tau tangles, while p-tau217 and GFAP inform on both Aβ deposition and tau pathology.