Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone.

Cari Stek,Muki Shey,Khuthala Mnika,Charlotte Schutz,Friedrich Thienemann,Robert J Wilkinson,Lutgarde Lynen,Graeme Meintjes

Open forum infectious diseases（2023）

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摘要

The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between genotype and TB-IRIS incidence or prednisone efficacy.

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关键词

prednisone,immune,tuberculosis-associated

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