Associations of polygenic risk scores for smoking heaviness and lifetime cannabis use with tobacco and cannabis co-use trajectories among African Americans

Jill A. Rabinowitz,Beth A. Reboussin,David W. Sosnowski,Sally I-Chun Kuo,Justin C. Strickland,Luis M. García-Marín,Miguel E. Rentería,Nathan Gillespie,Brion Maher,Nicholas S. Ialongo,Roland J. Thorpe,George Uhl

Drug and alcohol dependence（2023）

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摘要

•We examined smoking and cannabis polygenic scores with tobacco cannabis co-use.•Greater smoking genetic risk was linked to high, chronic tobacco and cannabis use.•Cannabis genetic risk was linked to experimental cannabis and high tobacco use.•Smoking genetic risk serves as a common liability for cannabis and tobacco use.

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关键词

Cannabis use,Tobacco use,Co-use,Polygenic risk scores,African American

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