Synovial and serum B-cell signature of autoantibody-negative rheumatoid arthritis versus autoantibody-positive rheumatoid arthritis and psoriatic arthritis.

Ludovico De Stefano,Serena Bugatti,Iolanda Mazzucchelli,Silvia Rossi,Blerina Xoxi,Emanuele Bozzalla Cassione,Terenzj Luvaro,Carlomaurizio Montecucco,Antonio Manzo

Rheumatology (Oxford, England)（2023）

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摘要

The synovial and serum immunophenotype indicative of B-lymphocyte involvement in autoantibody-negative RA differs from autoantibody-positive RA and more closely resembles that observed in polyarticular PsA. The pathobiological stratification of chronic inflammatory arthritides beyond clinical diagnosis may fuel personalised treatment strategies.

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