Association of CT-Derived Skeletal Muscle and Adipose Tissue Metrics with Frailty in Older Adults

Rationale and Objectives: Tools are needed for frailty screening of older adults. Opportunistic analysis of body composition could play a role. We aim to determine whether computed tomography (CT) -derived measurements of muscle and adipose tissue are associated with frailty. Materials and Methods: Outpatients aged >= 55 years consecutively imaged with contrast -enhanced abdominopelvic CT over a 3month interval were included. Frailty was determined from the electronic health record using a previously validated electronic frailty index (eFI). CT images at the level of the L3 vertebra were automatically segmented to derive muscle metrics (skeletal muscle area [SMA], skeletal muscle density [SMD], intermuscular adipose tissue [IMAT]) and adipose tissue metrics (visceral adipose tissue [VAT], subcutaneous adipose tissue [SAT]). Distributions of demographic and CT -derived variables were compared between sexes. Sexspecific associations of muscle and adipose tissue metrics with eFI were characterized by linear regressions adjusted for age, race, ethnicity, duration between imaging and eFI measurements, and imaging parameters. Results: The cohort comprised 886 patients (449 women, 437 men, mean age 67.9 years), of whom 382 (43%) met the criteria for prefrailty (ie, 0.10 < eFI <= 0.21) and 138 (16%) for frailty (eFI > 0.21). In men, 1 standard deviation changes in SMD (beta = -0.01, 95% confidence interval [CI], -0.02 to -0.001, P = .02) and VAT area (beta = 0.008, 95% CI, 0.0005-0.02, P = .04), but not SMA, IMAT, or SAT, were associated with higher frailty. In women, none of the CT -derived muscle or adipose tissue metrics were associated with frailty. Conclusion: We observed a positive association between frailty and CT -derived biomarkers of myosteatosis and visceral adiposity in a sex -dependent manner.