Transcriptomic Heterogeneity of Expansile Cribriform and Other Gleason Pattern 4 Prostate Cancer Subtypes

Meera R. Chappidi,Martin Sjöström,Nancy Y. Greenland,Janet E. Cowan,Avi S. Baskin,Kevin Shee,Jeffry P. Simko,Emily Chan,Bradley A. Stohr,Samuel L. Washington,Hao G. Nguyen,David A. Quigley,Elai Davicioni,Felix Y. Feng,Peter R. Carroll,Matthew R. Cooperberg

European Urology Oncology（2023）

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摘要

We identified transcriptomic heterogeneity within Gleason pattern 4 subtypes. Our findings demonstrate there is additional biological diversity not fully captured by histologic subtypes. This heterogeneity can be used to develop novel signatures and transcriptomic subtypes, which may help in further refining risk stratification following radical prostatectomy.

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关键词

Cribriform,Decipher,Genomic classifier,Prostate cancer,Risk stratification,Tumor subtypes

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