Infiltration of a Unique CD8 + CD274 + Cell Subgroup in Hepatocellular Carcinoma is Associated with Poor Clinical Outcomes.

Yong Zhang,Kaisa Cui, Yaoxiang Yang,Bingxin Liu,Minzheng Zhu,Hanqing Chen,Chong Zhao,Youlian Zhou,Yuqiang Nie

Journal of hepatocellular carcinoma（2023）

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摘要

Our findings illustrate that some HCC patients may have a poor prognosis despite high CD8 T-cell infiltration. These patients would probably benefit from IC inhibitor-based combination treatment.

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关键词

hepatocellular carcinoma, CD8A, CD274, molecular subtype, tumor microenvironment, immune overdrive

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