Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.

Sam Strickson,Kirsty F Houslay,Victor A Negri,Yoichiro Ohne, Tomas Ottosson,Roger B Dodd,Catherine Chaillan Huntington,Tina Baker,Jingjing Li,Katherine E Stephenson, Andy J O'Connor, J Sophie Sagawe,Helen Killick,Tom Moore,D Gareth Rees, Sofia Koch,Caroline Sanden, Yixin Wang,Elise Gubbins, Mahboobe Ghaedi,Roland Kolbeck, Saumyaa Saumyaa,Jonas S Erjefält,Gary P Sims,Alison A Humbles,Ian C Scott,Xavier Romero Ros,E Suzanne Cohen

The European respiratory journal（2023）

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摘要

Our study reveals for the first time that IL-33, RAGE and EGFR act together in an ST2-independent pathway in the airway epithelium and govern abnormal epithelial remodelling and muco-obstructive features in COPD.

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