Multi-spectral diffusion MRI mega-analysis in genetic generalized epilepsy: Relation to outcomes.

Barbara A K Kreilkamp,Christina Stier, Erik H Rauf,Pascal Martin,Silke Ethofer,Holger Lerche,Raviteja Kotikalapudi,Justus Marquetand,Peter Dechent,Niels K Focke

NeuroImage. Clinical（2023）

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摘要

We provide evidence that clinically defined GGE as a whole and GGE-subtypes harbor marked microstructural differences detectable with diffusion MRI. Moreover, we found an association between microstructural changes and treatment resistance. Our findings have important implications for future full-resolution multi-site studies when assessing GGE, its subtypes and ASM refractoriness.

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关键词

TBSS,ComBat,Multi-site,Multi-cohort

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