Mp22-13 occupational exposure to organic solvents and risk of bladder cancer

You have accessJournal of UrologyCME1 Apr 2023MP22-13 OCCUPATIONAL EXPOSURE TO ORGANIC SOLVENTS AND RISK OF BLADDER CANCER Shuai Xie, Melissa Friesen, Dalsu Barus, Molly Schwenn, Nathaniel Rothman, Alison Johnson, Margaret Karagas, Debra Silverman, and Stella Koutros Shuai XieShuai Xie More articles by this author , Melissa FriesenMelissa Friesen More articles by this author , Dalsu BarusDalsu Barus More articles by this author , Molly SchwennMolly Schwenn More articles by this author , Nathaniel RothmanNathaniel Rothman More articles by this author , Alison JohnsonAlison Johnson More articles by this author , Margaret KaragasMargaret Karagas More articles by this author , Debra SilvermanDebra Silverman More articles by this author , and Stella KoutrosStella Koutros More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003247.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Bladder cancer has been linked to several occupations that involve the use of solvents, but only perchloroethylene, used in the dry-cleaning industry, is classified as probably carcinogenic to humans. The role of other commonly used solvents is still unclear. Here, we evaluated exposure to solvents and risk of bladder cancer in 1182 incident cases and 1408 controls from a population-based study. METHODS: Exposure to 21 specific solvents was quantitatively assessed using a job-exposure matrix (CANJEM). Because exposure to benzene, toluene and xylene often co-occur, we created two additional sets of metrics of combined benzene, toluene and xylene (BTX) exposure: 1) CANJEM based BTX metrics and 2) Hybrid BTX metrics, which used a novel approach that integrated the CANJEM based BTX metrics together with responses to lifetime occupational histories and exposure-oriented modules to incorporate within-job, subject-specific details about tasks and chemicals into the exposure assessment. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated using logistic regression. RESULTS: Bladder cancer risks were significantly increased among those ever exposed to benzene (OR=1.63, 95%CI: 1.14-2.32), toluene (OR=1.60, 95%CI: 1.06-2.43), and xylene (OR=1.67, 95%CI: 1.13-2.48) individually. We observed a statistically significant exposure-response relationship for cumulative BTX exposure, with a stronger association observed with hybrid BTX metrics (ORQ1vsUnexposed=1.26, 95% CI: 0.83-1.90; ORQ2vsUnexposed=1.52, 95% CI: 1.00-2.31; ORQ3vsUnexposed=1.88, 95% CI: 1.24- 2.85; and ORQ4vsUnexposed=2.23, 95% CI: 1.35- 3.69) (p-trend=0.001) than with CANJEM based BTX metrics (p-trend=0.02). CONCLUSIONS: In our population-based study, BTX exposure was frequent among automobile mechanics, shoemakers, and painters. The identification of an increased risk for these solvents highlights a little recognized occupational exposure that may play a role in the etiology of bladder cancer. Source of Funding: This work was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics (ZIA CP010125-27) © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e301 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shuai Xie More articles by this author Melissa Friesen More articles by this author Dalsu Barus More articles by this author Molly Schwenn More articles by this author Nathaniel Rothman More articles by this author Alison Johnson More articles by this author Margaret Karagas More articles by this author Debra Silverman More articles by this author Stella Koutros More articles by this author Expand All Advertisement PDF downloadLoading ...