Combination of Polymeric Micelle Formulation of TGFβ Receptor Inhibitors and Paclitaxel Produce Consistent Response Across Different Mouse Models of TNBC.

Natasha Vinod,Duhyeong Hwang,Sloane Christian Fussell,Tyler Cannon Owens, Olaoluwa Christopher Tofade,Sage Copling,Jacob D Ramsey,Patrick D Rädler,Hannah M Atkins,Eric E Livingston,J Ashley Ezzell, Marina Sokolsky- Papkov,Hong Yuan,Charles M Perou,Alexander V Kabanov

bioRxiv : the preprint server for biology（2023）

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摘要

Paclitaxel is a widely used chemotherapy in breast cancer. However, response to single-agent chemotherapy is short-lived in a metastatic setting. This study shows the broad applicability of the therapeutic combination of TGFβ inhibitors with Paclitaxel across different TNBC subtypes.

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关键词

tgfβ receptor inhibitors,polymeric micelle formulation,paclitaxel

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