Reply to: Comments on "Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer".

International Journal of CancerEarly View LETTER TO THE EDITOR Reply to: Comments on “Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer” Pierre-Antoine Dugué, Corresponding Author Pierre-Antoine Dugué [email protected] orcid.org/0000-0003-2736-3023 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia Correspondence Pierre-Antoine Dugué, Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia. Email: [email protected]Search for more papers by this authorChenglong Yu, Chenglong Yu Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, AustraliaSearch for more papers by this authorAllison M. Hodge, Allison M. Hodge orcid.org/0000-0001-5464-2197 Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorEe Ming Wong, Ee Ming Wong Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorJiHoon E. Joo, JiHoon E. Joo Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorChol-Hee Jung, Chol-Hee Jung Melbourne Bioinformatics, University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorDaniel Schmidt, Daniel Schmidt Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia Department of Data Science and AI, Faculty of IT, Monash University, Clayton, Victoria, AustraliaSearch for more papers by this authorEnes Makalic, Enes Makalic Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorDaniel D. Buchanan, Daniel D. Buchanan orcid.org/0000-0003-2225-6675 Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia Melbourne Bioinformatics, University of Melbourne, Parkville, Victoria, Australia Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, AustraliaSearch for more papers by this authorGianluca Severi, Gianluca Severi orcid.org/0000-0001-7157-419X Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine Universités Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, FranceSearch for more papers by this authorDallas R. English, Dallas R. English orcid.org/0000-0001-7828-8188 Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorJohn L. Hopper, John L. Hopper Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorRoger L. Milne, Roger L. Milne Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorGraham G. Giles, Graham G. Giles Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorMelissa C. Southey, Melissa C. Southey orcid.org/0000-0002-6313-9005 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this author Pierre-Antoine Dugué, Corresponding Author Pierre-Antoine Dugué [email protected] orcid.org/0000-0003-2736-3023 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia Correspondence Pierre-Antoine Dugué, Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia. Email: [email protected]Search for more papers by this authorChenglong Yu, Chenglong Yu Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, AustraliaSearch for more papers by this authorAllison M. Hodge, Allison M. Hodge orcid.org/0000-0001-5464-2197 Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorEe Ming Wong, Ee Ming Wong Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorJiHoon E. Joo, JiHoon E. Joo Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorChol-Hee Jung, Chol-Hee Jung Melbourne Bioinformatics, University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorDaniel Schmidt, Daniel Schmidt Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia Department of Data Science and AI, Faculty of IT, Monash University, Clayton, Victoria, AustraliaSearch for more papers by this authorEnes Makalic, Enes Makalic Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorDaniel D. Buchanan, Daniel D. Buchanan orcid.org/0000-0003-2225-6675 Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia Melbourne Bioinformatics, University of Melbourne, Parkville, Victoria, Australia Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, AustraliaSearch for more papers by this authorGianluca Severi, Gianluca Severi orcid.org/0000-0001-7157-419X Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine Universités Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, FranceSearch for more papers by this authorDallas R. English, Dallas R. English orcid.org/0000-0001-7828-8188 Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorJohn L. Hopper, John L. Hopper Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorRoger L. Milne, Roger L. Milne Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorGraham G. Giles, Graham G. Giles Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this authorMelissa C. Southey, Melissa C. Southey orcid.org/0000-0002-6313-9005 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, AustraliaSearch for more papers by this author First published: 30 June 2023 https://doi.org/10.1002/ijc.34644Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Dugué PA, Yu C, Hodge AM, et al. Methylation scores for smoking, alcohol consumption, and body mass index and risk of seven types of cancer. Int J Cancer. 2023; 153(3): 489-498. 2Yu H, Raut JR, Schöttker B, Holleczek B, Zhang Y, Brenner H. Individual and joint contributions of genetic and methylation risk scores for enhancing lung cancer risk stratification: data from a population-based cohort in Germany. Clin Epigenetics. 2020; 12: 1-11. 3Kresovich JK, Xu Z, O'Brien KM, et al. Blood DNA methylation profiles improve breast cancer prediction. Mol Oncol. 2022; 16: 42-53. 4Yu C, Hodge AM, Wong EM, et al. Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation? Epigenetics. 2022; 17: 1838-1847. 5Kachuri L, Graff RE, Smith-Byrne K, et al. 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