Doxorubicin-Fe(III)-Gossypol Infinite Coordination Polymer@PDA:CuO₂ Composite Nanoparticles for Cost-Effective Programmed Photothermal-Chemodynamic-Coordinated Dual Drug Chemotherapy Trimodal Synergistic Tumor Therapy

To achieve the maximum therapeutic effects and minimizeadverseeffects of trimodal synergistic tumor therapies, a cost-effectiveprogrammed photothermal (PTT)-chemodynamic (CDT)-coordinated dualdrug chemotherapy (CT) trimodal synergistic therapy strategy in chronologicalorder is proposed. According to the status or volumes of the tumors,the intensity and time of each therapeutic modality are optimized,and three modalities are combined programmatically and work in chronologicalorder. The optimal synergistic therapy begins with high-intensityPTT for 10 min to ablate larger tumors, followed by medium-intensityCDT for several hours to eliminate medium-sized tumors, and then low-intensitycoordinated dual drugs CT lasts over 48 h to clear smaller residualtumors. Composite nanoparticles, made of Fe-coordinated polydopaminemixed with copper peroxide as the cores and their surface dotted withlots of doxorubicin-Fe(III)-gossypol infinite coordination polymers(ICPs), have been developed to implement the strategy. These compositenanoparticles show excellent synergistic effects with the minimumdose of therapeutic agents and result in nearly 100% tumor inhibitionfor mice bearing PC-3 tumors and no observed recurrence within 60days of treatment. The ratios of the different therapeutic agentsin the composite nanoparticles can be adjusted to accommodate differenttypes of tumors with this cost-effective programmed trimodal therapystrategy.