Gut microbiome generated phenylacetylglutamine from dietary protein is associated with Crohn's Disease and exacerbates colitis in mouse model possibly via platelet activation.

Taken together, ppdc-carrying Proteobacteria generated PAGln from dietary protein is associated with CD and exacerbates colitis possibly via platelet-induced coagulation and inflammation These results suggest that PAGln is a potential early diagnostic marker and therapeutic target of CD.