Long non-coding RNAs CCAT1 and CCAT2 in colorectal liver metastases are tumor-suppressive via MYC interaction and might predict patient outcomes.

Clemens Franz,Michael Wuehrl,Sibylle Hartmann,Fee Klupp,Thomas Schmidt,Martin Schneider

PloS one（2023）

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摘要

Our findings demonstrate tumor-suppressive functions of lncRNAs CCAT1 and CCAT2 in colorectal liver metastases. They suppress Wnt signaling directly and indirectly through target gene MYC and might prevent further metastatic spread from colorectal liver metastases.

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关键词

colorectal liver metastases,ccat2,rnas,myc interaction,non-coding,tumor-suppressive

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