CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension.

Hua Su,Huiqi Zhu, Sihao Wang,Yeping Li,Chao Yan, Jiaoyan Wang,Kejing Ying

Respiratory research（2023）

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摘要

CircItgb5 promoted the transition of PASMCs to synthetic phenotype by interacting with miR-96-5p and Uba1 protein. Knockdown of circItgb5 mitigated pulmonary arterial pressure, pulmonary vascular remodeling and right ventricular hypertrophy. Overall, circItgb5 has the potential for application as a therapeutic target for PAH.

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关键词

circItgb5, miR-96-5p, Uba1, Pulmonary arterial smooth muscle cells, Pulmonary arterial hypertension

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