Brain imaging signatures in amyotrophic lateral sclerosis: Correlation with peripheral motor degeneration.

Sung-Ju Hsueh,Chi-Chao Chao,Ta-Fu Chen,Ya-Fang Chen,Hsueh-Wen Hsueh,Li-Kai Tsai,Wen-Chau Wu,Sung-Tsang Hsieh

Annals of clinical and translational neurology（2023）

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摘要

This study indicated that clinical assessment of muscle strength and routine measurements on nerve conduction studies provided surrogate markers of brain structural changes for ALS. Furthermore, these findings suggested parallel involvement of both upper and lower motor neurons in ALS.

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