Retromer Stabilization Improves Cognitive Function and Synaptic Plasticity in a Mouse Model of Down Syndrome.

Mary Elizabeth Curtis,Tiffany Smith,Miroslav Nenov,Benjamin E Blass,Domenico Praticò

Journal of Alzheimer's disease : JAD（2023）

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摘要

Pharmacological stabilization of the retromer complex improves synaptic plasticity and memory in a mouse model of Down syndrome. These results support the therapeutic potential of pharmacological retromer stabilization for individual with Down syndrome.

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关键词

synaptic plasticity,down syndrome,retromer stabilization,cognitive function,mouse model

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