Effects of in-utero personal exposure to PM 2.5 sources and components on birthweight

In-utero exposure to fine particulate matter (PM 2.5 ) and specific sources and components of PM 2.5 have been linked with lower birthweight. However, previous results have been mixed, likely due to heterogeneity in sources impacting PM 2.5 and due to measurement error from using ambient data. Therefore, we investigated the effect of PM 2.5 sources and their high-loading components on birthweight using data from 198 women in the 3rd trimester from the MADRES cohort 48-h personal PM 2.5 exposure monitoring sub-study. The mass contributions of six major sources of personal PM 2.5 exposure were estimated for 198 pregnant women in the 3rd trimester using the EPA Positive Matrix Factorization v5.0 model, along with their 17 high-loading chemical components using optical carbon and X-ray fluorescence approaches. Single- and multi-pollutant linear regressions evaluated the association between personal PM 2.5 sources/components and birthweight, adjusting for gestational age, maternal age, race, infant sex, parity, diabetes status, temperature, maternal education, and smoking history. Participants were predominately Hispanic (81%), with a mean (SD) gestational age of 39.1 (1.5) weeks and age of 28.2 (6.0) years. Mean birthweight was 3295.8 g (484.1) and mean PM 2.5 exposure was 21.3 (14.4) µg/m 3 . A 1 SD increase in the mass contribution of the fresh sea salt source was associated with a 99.2 g decrease in birthweight (95% CI − 197.7, − 0.6), and aged sea salt was associated with a 70.1 g decrease in birthweight (95% CI − 141.7, 1.4). Magnesium, sodium, and chlorine were associated with lower birthweight, which remained after adjusting for PM 2.5 mass. This study found evidence that major sources of personal PM 2.5 including fresh and aged sea salt were negatively associated with birthweight, with the strongest effect on birthweight from Na and Mg. The effect of crustal and fuel oil sources differed by infant sex with negative associations seen in boys compared to positive associations in girls.