Neuroprotection after cardiac arrest with 2-iminobiotin: a single center phase IIa study on safety, tolerability, and pharmacokinetics.

M M Admiraal, D C Velseboer, H Tjabbes,P Vis,C Peeters-Scholte,J Horn

Frontiers in neurology（2023）

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摘要

The administration of 2-IB to adults after OHCA is feasible and safe. PK can be well predicted with correction for renal function on admission. Efficacy studies with 2-IB after OHCA are needed.

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关键词

cardiac arrest, neuroprotection, nitric oxide synthase, 2-iminobiotin, pharmacokinetics

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