Identification of miRNAs regulating MAPT expression and their analysis in plasma of patients with dementia.

Paola Piscopo,Margherita Grasso,Valeria Manzini, Andrea Zeni,Michele Castelluzzo,Francesca Fontana,Giuseppina Talarico,Anna Elisa Castellano,Roberto Rivabene,Alessio Crestini,Giuseppe Bruno,Leonardo Ricci,Michela A Denti

Frontiers in molecular neuroscience（2023）

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摘要

Our results seem to identify miR-92a-3p and miR-320a as possible good biomarkers to discriminate AD from HC, while miR-320b to discriminate FTD from HC, particularly in males. Combining three miRNAs improves the accuracy only in females, particularly for differential diagnosis (FTD vs. AD) and to distinguish FTD from HC.

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关键词

dementia, MAPT, microRNA-capture affinity technology, microRNA, biomarkers, Alzheimer's disease, Frontotemporal dementia

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