Combinatorial immune refocusing within the influenza hemagglutinin head elicits cross-neutralizing antibody responses.

Generalization of trihead antigen platform to several H1 hemagglutinins, including hyperglycosylated and hypervariable variantsTrimer-stabilizing mutations in trihead nanoparticle immunogens lead to lower levels of non-neutralizing antibody responses in both mice and rabbitsHyperglycosylated triheads elicit higher antibody responses against broadly neutralizing epitopes.