Sialic acid metabolism orchestrates transcellular connectivity and signalling in glioblastoma.

Ugne Kuliesiute,Kevin Joseph,Jakob Straehle,Vidhya Madapusi Ravi,Jan Kueckelhaus,Jasim Kada Benotmane,Junyi Zhang,Andreas Vlachos,Juergen Beck,Oliver Schnell,Urte Neniskyte,Dieter Henrik Heiland

Neuro-oncology（2023）

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摘要

Our results indicate that sialic acid is essential for the establishment of GBM tumor and its cellular network. They highlight the importance of sialic acid for glioblastoma pathology and suggest that dynamics of sialylation have the potential to be targeted therapeutically.

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sialic acid metabolism,transcellular connectivity

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