Targeting NETs using dual-active DNase1 variants.

Hanna Englert, Josephine Göbel, Danika Khong, Maryam Omidi,Nina Wolska,Sandra Konrath,Maike Frye,Reiner K Mailer,Manu Beerens, Julian C Gerwers,Roger J S Preston,Jacob Odeberg,Lynn M Butler,Coen Maas,Evi X Stavrou,Tobias A Fuchs,Thomas Renné

Frontiers in immunology（2023）

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摘要

Therefore, the dual-active DNase1 mutant is a promising tool for neutralization of DNA and NETs with potential therapeutic applications for interference with thromboinflammatory disease states.

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关键词

nets,dual-active

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