Thyroid Function Tests in Children and Adolescents with Trisomy 21: Definition of Syndrome-Specific Reference Ranges.

Alessandro Cattoni,Silvia Molinari,Giulia Capitoli,Nicoletta Masera,Maria Laura Nicolosi,Silvia Barzaghi,Giulia Marziali,Alessandra Lazzerotti, Alessandra Gazzarri,Chiara Vimercati,Debora Sala,Andrea Biondi,Stefania Galimberti,Chiara Fossati

The Journal of clinical endocrinology and metabolism（2023）

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摘要

By longitudinally assessing TFT in a wide pediatric DS population, we outlined the syndrome-specific reference nomograms for TSH, FT3 and FT4 and demonstrated a persistent upward shift of TSH compared to non-syndromic children.

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Down syndrome, thyroid function tests, reference values, hypothyroidism, thyroxine, thyrotropin

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