Progression of Cardiac Abnormalities in Hutchinson-Gilford Progeria Syndrome: A Prospective Longitudinal Study

HomeCirculationVol. 147, No. 23Progression of Cardiac Abnormalities in Hutchinson-Gilford Progeria Syndrome: A Prospective Longitudinal Study No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextProgression of Cardiac Abnormalities in Hutchinson-Gilford Progeria Syndrome: A Prospective Longitudinal Study Flemming Javier Olsen, Leslie B. Gordon, Leslie Smoot, Monica E. Kleinman, Marie Gerhard-Herman, Sheila M. Hegde, Srinivasan Mukundan, Taylor Mahoney, Joseph Massaro, Sendy Ha and Ashwin Prakash Flemming Javier OlsenFlemming Javier Olsen https://orcid.org/0000-0001-9511-8375 From the Departments of Cardiology (F.J.O., L.S., S.H., A.P.), Boston Children’s Hospital and Harvard Medical School, MA. Department of Pediatrics, Harvard Medical School, Boston, MA (F.J.O., L.B.G., L.S., M.E.K., A.P.). Department of Cardiology, Copenhagen University Hospital–Herlev and Gentofte, Hellerup, Denmark (F.J.O.). Search for more papers by this author , Leslie B. GordonLeslie B. Gordon https://orcid.org/0000-0002-4353-2520 Anesthesia (L.B.G., M.E.K.), Boston Children’s Hospital and Harvard Medical School, MA. Department of Pediatrics, Harvard Medical School, Boston, MA (F.J.O., L.B.G., L.S., M.E.K., A.P.). Department of Pediatrics, Hasbro Children’s Hospital, and Warren Alpert Medical School of Brown University, Providence, RI (L.B.G.). Search for more papers by this author , Leslie SmootLeslie Smoot From the Departments of Cardiology (F.J.O., L.S., S.H., A.P.), Boston Children’s Hospital and Harvard Medical School, MA. Department of Pediatrics, Harvard Medical School, Boston, MA (F.J.O., L.B.G., L.S., M.E.K., A.P.). Search for more papers by this author , Monica E. KleinmanMonica E. Kleinman https://orcid.org/0000-0002-4318-4378 Critical Care Medicine (M.E.K.), Boston Children’s Hospital and Harvard Medical School, MA. Anesthesia (L.B.G., M.E.K.), Boston Children’s Hospital and Harvard Medical School, MA. Department of Pediatrics, Harvard Medical School, Boston, MA (F.J.O., L.B.G., L.S., M.E.K., A.P.). Search for more papers by this author , Marie Gerhard-HermanMarie Gerhard-Herman Departments of Medicine, Cardiovascular Medicine (M.G.-H., S.M.H.), Brigham and Women’s Hospital, Boston, MA. Search for more papers by this author , Sheila M. HegdeSheila M. Hegde https://orcid.org/0000-0001-8157-8899 Departments of Medicine, Cardiovascular Medicine (M.G.-H., S.M.H.), Brigham and Women’s Hospital, Boston, MA. Search for more papers by this author , Srinivasan MukundanSrinivasan Mukundan Radiology (S.M.), Brigham and Women’s Hospital, Boston, MA. Search for more papers by this author , Taylor MahoneyTaylor Mahoney Department of Mathematics and Statistics, Boston University, MA (T.M., J.M.). Harvard Clinical Research Institute, Boston, MA (T.M., J.M.). Search for more papers by this author , Joseph MassaroJoseph Massaro Department of Mathematics and Statistics, Boston University, MA (T.M., J.M.). Harvard Clinical Research Institute, Boston, MA (T.M., J.M.). Search for more papers by this author , Sendy HaSendy Ha From the Departments of Cardiology (F.J.O., L.S., S.H., A.P.), Boston Children’s Hospital and Harvard Medical School, MA. Search for more papers by this author and Ashwin PrakashAshwin Prakash Correspondence to: Ashwin Prakash, MD, Department of Cardiology, Boston Children’s Hospital, 300 Longwood Ave, Boston, MA 02115. Email E-mail Address: [email protected] From the Departments of Cardiology (F.J.O., L.S., S.H., A.P.), Boston Children’s Hospital and Harvard Medical School, MA. Department of Pediatrics, Harvard Medical School, Boston, MA (F.J.O., L.B.G., L.S., M.E.K., A.P.). Search for more papers by this author Originally published5 Jun 2023https://doi.org/10.1161/CIRCULATIONAHA.123.064370Circulation. 2023;147:1782–1784This article is commented on by the following:Readily Available Tools to Detect Progerin and Cardiac Disease Progression in Hutchinson-Gilford Progeria SyndromeFootnotesRegistration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00916747.For Sources of Funding and Disclosures, see page 1784.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Ashwin Prakash, MD, Department of Cardiology, Boston Children’s Hospital, 300 Longwood Ave, Boston, MA 02115. Email ashwin.[email protected].chboston.orgReferences1. Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith ACM, Perry MB, Brewer CC, Zalewski C, Kim HJ, Solomon B, et al. Phenotype and course of Hutchinson–Gilford progeria syndrome.N Engl J Med. 2008; 358:592–604. doi:10.1056/NEJMoa0706898CrossrefMedlineGoogle Scholar2. Gordon LB, Shappell H, Massaro J, D’Agostino RB, Brazier J, Campbell SE, Kleinman ME, Kieran MW. Association of lonafarnib treatment vs no treatment with mortality rate in patients with Hutchinson-Gilford Progeria syndrome.JAMA. 2018; 319:1687–1695. doi: 10.1001/jama.2018.3264CrossrefMedlineGoogle Scholar3. Prakash A, Gordon LB, Kleinman ME, Gurary EB, Massaro J, D’Agostino R, Kieran MW, Gerhard-Herman M, Smoot L. Cardiac abnormalities in patients with Hutchinson-Gilford progeria syndrome.JAMA Cardiol. 2018; 3:326–334. doi: 10.1001/jamacardio.2017.5235CrossrefMedlineGoogle Scholar4. Lopez L, Colan SD, Frommelt PC, Ensing GJ, Kendall K, Younoszai AK, Lai WW, Geva T. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the pediatric measurements writing group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council.J Am Soc Echocardiogr. 2010; 23:465–495. doi: 10.1016/j.echo.2010.03.019CrossrefMedlineGoogle Scholar5. Lai WW, Mertens LL, Cohen MS, Geva T eds. Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult. Wiley-Blackwell; 2016.CrossrefGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited ByEriksson M, Haugaa K and Revêchon G (2023) Readily Available Tools to Detect Progerin and Cardiac Disease Progression in Hutchinson-Gilford Progeria Syndrome, Circulation, 147:23, (1745-1747), Online publication date: 6-Jun-2023.Related articlesReadily Available Tools to Detect Progerin and Cardiac Disease Progression in Hutchinson-Gilford Progeria SyndromeMaria Eriksson, et al. Circulation. 2023;147:1745-1747 June 6, 2023Vol 147, Issue 23 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.064370PMID: 37276254 Originally publishedJune 5, 2023 Keywordsprogeriadisease progressionventricular dysfunctionleftPDF download Advertisement SubjectsEchocardiographyGeneticsValvular Heart Disease