Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation.

Lydia Meziani,Marine Gerbé de Thoré,Céline Clémenson,Winchygn Liu,Pierre-Antoine Laurent,Michele Mondini,Marie-Catherine Vozenin,Eric Deutsch

Journal for immunotherapy of cancer（2023）

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摘要

These data emphasize the importance of the dosing regimen for anti-CD73 treatment to improve tumor response to IR and identify iCOS as part of the underlying molecular mechanisms. Our data suggest that the selection of appropriate dosing regimen is required to optimize the therapeutic efficacy of immunotherapy-radiotherapy combinations.

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关键词

cd73 blockade,radiotherapy,optimal dosing regimen,tumor response,icos downregulation

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