Evaluation of circulating tumor DNA by electropherogram analysis and methylome profiling in high-risk neuroblastomas.

Eva María Trinidad,Antonio Juan-Ribelles, Giulia Pisano,Victoria Castel,Adela Cañete,Marta Gut,Simon Heath,Jaime Font de Mora

Frontiers in oncology（2023）

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摘要

Our results refine the use of electropherogram profiles to optimize sample selection for subsequent high-throughput analysis and support the use of liquid biopsy followed by enzymatic conversion of unmethylated cysteines to assess the methylomes of neuroblastoma patients.

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关键词

liquid biopsy,high-risk neuroblastoma,DNA mehtylation,ctDNA / normal cfDNA ratio,enzymatic methyl-sequencing (EM-seq)

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