Patchouli alcohol induces G 0 /G 1 cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage.

Chi-Yen Liang,Kai-Fu Chang,Ya-Chih Huang,Xiao-Fan Huang,Gwo-Tarng Sheu, Chia-Feng Kuo,Chih-Yen Hsiao,Nu-Man Tsai

Thoracic cancer（2023）

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摘要

PA induced ROS-mediated DNA damage, triggered cell cycle arrest and apoptosis, attenuated drug resistance and cancer stem cell phenotypes, and synergistically inhibited proliferation in combination with cisplatin. These findings suggest that PA has the potential to be used for the treatment of NSCLC with or without VCR resistance.

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关键词

apoptosis, non-small cell lung cancer, patchouli alcohol, ROS, vincristine resistance

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