Inhibition of the extracellular enzyme ADAMTS4 prevents cardiac fibrosis and dysfunction.

Maria Vistnes,Pugazendhi Murugan Erusappan,Athiramol Sasi,Einar Sjaastad Nordén, Kaja Bergo,Andreas Romaine,Ida Gjervold Lunde,Lili Zhang,Maria Belland Olsen,Jonas Øgaard,Cathrine Rein Carlson, Christian Hjorth Wang, Jon Riise,Christen P Dahl,Arnt Eltvedt Fiane, IdaMarie Hauge-Iversen,Emil Espe,Arne Olav Melleby,Theis Tønnessen,Jan Magnus Aronsen,Ivar Sjaastad,Geir Christensen

Cardiovascular research（2023）

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摘要

Inhibition of ADAMTS4 improves cardiac function and reduces collagen accumulation in rats with cardiac pressure overload, possibly through a not previously known cleavage of molecules that control TGF-β availability. Targeting ADAMTS4 may serve as a novel strategy in heart failure treatment, in particular in heart failure with fibrosis and diastolic dysfunction.

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