New pro-inflammatory cytokine IL-40 is produced by activated neutrophils and plays a role in the early stages of seropositive rheumatoid arthritis.

Adéla Navrátilová,Viktor Bečvář,Hana Hulejová,Michal Tomčík,Lucie Štolová,Heřman Mann,Olga Růžičková,Olga Šléglová,Jakub Závada,Karel Pavelka,Jiří Vencovský,Ladislav Šenolt,Lucie Andrés Cerezo

RMD open（2023）

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摘要

We showed that IL-40 is significantly up-regulated in seropositive ERA and decreases after conventional therapy. Moreover, neutrophils are an important source of IL-40 in RA, and its release is potentiated by cytokines and NETosis. Thus, IL-40 may play a role in ERA.

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Early Rheumatoid Arthritis, Autoantibodies, Cytokines

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